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Malaria is a serious infectious disease caused by a protozoan parasite called Plasmodium, which is transmitted to humans through the bite of infected female Anopheles mosquitoes. After entering the bloodstream, the parasite travels first to the liver, where it multiplies. Later, it infects red blood cells, causing them to burst and release toxins into the blood.

As the infection progresses, malaria affects several organs, but the spleen is one of the primary organs impacted. The spleen plays an important role in filtering the blood, removing old or damaged red blood cells, and fighting infections. When malaria parasites destroy large numbers of red blood cells, the spleen becomes overactive, enlarges, and sometimes gets damaged. This condition is known as splenomegaly, a common symptom in malaria patients.

Other organs can also be affected indirectly due to the widespread destruction of red blood cells and lack of oxygen supply in severe cases. The liver, brain, and kidneys may show complications, especially in severe forms of malaria like Plasmodium falciparum infection. However, the spleen remains the most directly and consistently affected organ because it is the main site where infected blood cells are trapped and destroyed.

Typical symptoms of malaria include high fever, chills, headache, sweating, nausea, and anemia due to the breakdown of red blood cells. If untreated, severe malaria can lead to life-threatening complications such as organ failure or cerebral malaria.

In conclusion, among the given options, the correct answer is spleen because it is the organ most affected during a malaria infection. The disease causes inflammation, enlargement, and increased activity of the spleen as it tries to fight the parasite invading the blood.